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Tamoxifen is used for treating breast cancer that has spread to other sites in the body. It is also used along with other medicines to treat other types of breast cancer. It is used in women who are at high risk of breast cancer and in women with DCIS (after surgery and radiation) to decrease the risk of developing breast cancer. It may also be used for other conditions as determined by your doctor. How to use Use Tamoxifen as directed by your doctor. Check the label on the medicine for exact dosing instructions. Tamoxifen comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Tamoxifen refilled. Tamoxifen may be taken by mouth with or without food. Take Tamoxifen with water or another nonalcoholic liquid. Swallow this medication whole. Do not break, crush, or chew before swallowing. Continue taking Tamoxifen even if you feel well. Do not miss any doses. Take Tamoxifen at the same time each day.